Action
There are unpleasant moments during role transition. Sometimes they can be demoralising. Always look for strategies to work through issues so you can remain in the role. If you leave you begin the transition experience again in the next role, which resets the sequence of phases, including the unpleasant bits.
Risks/Opportunities/Surprises
Sometimes you do land in the wrong role or organisation. You may even see some of the indicators of a failing transition, such as a poor relationship with your boss. If you engage in a thorough analysis of your situation, consult your support network to ensure you are not operating out of stress or disappointment, you may consider changing roles. There is no point damaging your health or reputation if the issues causing you trouble appear to be entrenched and unresolvable.